与口腔潜在恶性疾病相关的口腔癌中新出现的口腔癌之间的差异:系统性审查和元分析
Eduardo David Piemonte1, Gerardo Marcelo Gilligan1, Federico Garola1
1Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Córdoba, Argentina.
概括
口腔状细胞癌新发 (OSCC-dn) 比顺序性OSCC (s-OSCC) 更常见和更具攻击性. OSCC-dn呈现出更大的瘤,更多的转移,以及更差的生存率,需要针对性的预防策略.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 流行病学 流行病学
背景情况:
- 口腔状细胞癌 (OSCC) 可以在潜在的恶性疾病后出现新发症或连续发生.
- 了解这两个途径的不同特征对于有效的管理和预防至关重要.
研究的目的:
- 分析顺序性口腔状细胞癌 (s-OSCC) 与新出现的OSCC (OSCC-dn) 的频率.
- 探索s-OSCC和OSCC-dn之间的临床病理差异.
主要方法:
- 在主要数据库 (PubMed,Scopus,Cochrane,Google Scholar) 进行了系统的文献搜索,截至2023年1月.
- 包括分析频率,临床,生物,人口,生物标志物和预后特征的研究.
- 通过研究和卫生质量机构工具和纽卡斯尔-太华尺度来评估研究质量.
主要成果:
- OSCC-dn占71%的病例,而s-OSCC占29% (P = .00). 在这些病例中,OSCC-dn占71%的病例,而s-OSCC占29% (P = .00).
- s-OSCC与较小的瘤大小 (T1/T1+T2) 和较少的转移有关.
- OSCC-dn显示了较大的瘤大小,更多的区域/远程转移,晚期和更差的存活率.
结论:
- s-OSCC的发生频率低于预期.
- OSCC-dn表现出明显的临床,生物和预后特征.
- 建议采取新的预防策略,包括紧急转诊OSCC-dn.
相关概念视频
Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancers Originate from Somatic Mutations in a Single Cell
11.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.9K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K


