评估初潮时的年龄与青少年心理健康之间的因果关系:孟德尔的随机化研究
Adrian Dahl Askelund1,2,3, Robyn E Wootton4,5,6,7, Fartein A Torvik8,9
1Department of Psychology, University of Oslo, Oslo, Norway. jaaskelu@uio.no.
BMC medicine
|April 12, 2024
概括
早期的青春期,由初潮时的年龄表明,与青少年抑郁症的增加有关. 这项研究表明存在因果关系,影响特定的心理健康领域,而不是整体青少年福祉.
科学领域:
- 生殖健康 生殖健康
- 青少年精神病学 青少年精神病学
- 遗传流行病学遗传流行病学
背景情况:
- 青春期的时间显著影响青少年的心理健康.
- 初潮的早期年龄与更高的青少年抑郁症率有关.
- 以前的研究表明存在潜在的因果关系,需要进一步调查.
研究的目的:
- 调查初经年龄与青少年心理健康领域之间的因果关系.
- 使用多种因果推理方法来获得强有力的证据.
- 为了检查超越抑郁症的影响,包括其他心理健康状况.
主要方法:
- 采用注册报告设计,采用挪威母亲,父亲和儿童队列研究的大数据集 (N=13,398).
- 综合多重回归,一样本和两样本的门德尔随机化 (MR) 和负对照分析.
- 评估了初潮时的年龄和各种青少年心理健康结果之间的因果关系.
主要成果:
- 早期初潮的多重回归与较高的抑郁症状有关 (β = -0.11).
- 一个样本的MR表明对抑郁症状 (β = -0.07) 和抑郁症诊断 (OR = 0.74) 有潜在的因果作用.
- 敏感性分析 (负对照,两样MR) 支持了这些发现,尽管多变量MR暗示了儿童体型的混.
结论:
- 证据支持初潮早期年龄和青少年抑郁症诊断之间的因果关系.
- 在考虑了抑郁症和混因素后,对于其他心理健康领域没有发现一致的影响.
- 较早的初潮会影响特定的心理健康领域,而不是青少年的广泛心理健康.
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