果 (Citrus bergamia) 花精油对抗口腔病原体的潜在作用
Muhammad Imran Aziz1, Muhammad Mohtasheemul Hasan1, Riaz Ullah2
1Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan.
BMC complementary medicine and therapies
|April 12, 2024
概括
类百加花精油显示出强大的抗氧化剂,抗微生物和抗菌膜特性,可以对抗口腔病原体. 这种天然化合物为抗生素提供了一个有希望的替代品,用于对抗耐药性口腔感染.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 计算生物学 计算生物学
背景情况:
- 口腔细菌感染中的抗生素耐药性需要替代治疗策略.
- 精油被探索为潜在的抗细菌感染和生物膜的药物.
- 香 (Citrus bergamia) 花精油对其对口腔病原体的有效性进行了研究.
研究的目的:
- 为了评估果花精油的化学成分.
- 为了评估其在体,抗氧化剂,抗微生物,抗菌膜和抗定数感应活动.
- 确定其作为治疗口腔细菌感染的替代疗法的潜力.
主要方法:
- 气色谱-质谱 (GC-MS) 用于化学分析.
- 包括利宾斯基法则,生物可用性和PASS分析在内的in silico方法.
- 用关键的转录调节器进行分子对接研究.
- 抗氧化剂检测 (DPPH,H2O2,FRAP) 进行.
- 抗微生物,抗菌膜和抗定数感应测试.
主要成果:
- GC-MS确定了17种化合物,其中1,6-Octadien-3-ol,3,7-dimethyl,l-limonene和p-menth-1-ol是主要组成部分.
- 在分析表明良好的药物相似性和预测的抗菌活性.
- 该油表现出显著的抗氧化能力,抑制DPPH和H2O2,以及高FRAP值.
- 显示出显著的抗菌活性,对抗巴氏菌体和巴氏阳菌体.
- 展示了强大的剂量依赖抗生素 (52.1-69.5%) 和抗定数感应 (4-16毫米) 效果.
结论:
- 果精油具有显著的抗氧化,抗微生物和抗菌膜活性.
- 油对经过测试的口腔病原体有效,包括Bacillus物种.
- 它为治疗口腔细菌感染和生物膜提供了一个可行的天然替代品.
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