胚芽中心和CD39高CD73+ B细胞在与年龄相关的桃体内卷变中的作用
Rocío Pastor1,2, Juliana Puyssegur1, M Paula de la Guardia1
1Institute of Immunology, Genetics and Metabolism (INIGEM), Clinical Hospital 'José de San Martín', University of Buenos Aires (UBA), National Council for Scientific and Technological Research (CONICET), Av Córdoba 2351, C1120AAF, Buenos Aires, CABA, Argentina.
Immunity & ageing : I & A
|April 12, 2024
概括
桃体中的免疫细胞随着年龄的增长而发生变化,从病原体防御转向免疫抑制. 较老的桃体显示出较少的生殖中心B细胞,但更多的记忆B细胞和免疫抑制环境.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 桃体是上空消化道中的关键免疫器官,类似于淋巴结.
- 它们被认为是系统免疫和粘膜免疫的诱导部位.
- 据信,桃体在青春期后会不发育,这促使人们对与年龄相关的免疫细胞变化进行研究.
研究的目的:
- 研究衰老和慢性炎症对桃体免疫细胞的影响.
- 分析B细胞和T毛囊辅助细胞群的年龄相关变化.
- 了解桃体免疫细胞在一生中的功能变化.
主要方法:
- 从不同年龄组的个体中分离桃体单核细胞 (TMC).
- 流细胞计分析以量化特定的免疫细胞群 (例如B细胞,Tfh细胞).
- 对ex vivo免疫细胞增殖和代谢活动的评估.
主要成果:
- 生殖中心B细胞 (BGC) 和T毛囊辅助生殖中心细胞 (TfhGC) 的年龄相关下降.
- 随着年龄的增长,记忆B细胞和地幔区T毛囊辅助细胞 (mTfh) 的增加.
- 在老年人中,积累了 ATP 代谢的 B 细胞 (CD20+CD39高CD73+).
- 年轻的个体在新鲜的TMC中显示出更高比例的增殖性免疫细胞.
结论:
- 桃体免疫细胞景观随着年龄的增长而重塑,从病原体防御转向免疫抑制.
- 老化的桃体可能会形成一种免疫抑制的微环境,这对于组织损伤控制至关重要.
- 孤立的较老的桃体B细胞表现出与较年轻的细胞相似的增殖,这表明微环境的影响.
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