在多发性硬化症中状扩大的时间轨迹
Athina Andravizou1, Sotiria Stavropoulou De Lorenzo1, Evangelia Kesidou1
1Multiple Sclerosis Center, Second Department of Neurology, School of Medicine, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.
Healthcare (Basel, Switzerland)
|April 13, 2024
概括
在多发性硬化症 (MS) 的早期阶段,胸膜 (CP) 体积会扩大,与疾病活动相关. 在早期多发性硬化中,CP体积分析最有价值,但在进展性多发性硬化中,其价值较低.
科学领域:
- 神经免疫学 神经免疫学
- 中枢神经系统 (CNS) 恒常状态 恒常状态
- 神经炎症是一种神经炎症.
背景情况:
- 冠状动脉 (CP) 作为中枢神经系统的守门员,调节其内部环境.
- 越来越多的证据将CP变化与多发性硬化症 (MS) 病原体联系起来,尽管机制尚不清楚.
- 在MS早期 (临床隔离综合征,放射学隔离综合征,复发性复发性MS) 发生CP扩大和炎症.
研究的目的:
- 为了澄清多发性硬化症中状体体积 (CPV) 变化的病理意义.
- 要突出CP体积分析在MS中的局限性和潜在陷.
- 评估CP体积评估在不同MS疾病阶段的有用性.
主要方法:
- 关于CP体积及其与MS特征的相关性现有文献的审查.
- 与MRI发现和临床结果相关的状与总内体积 (CP/TIV) 的比率的分析.
- 早期多发性硬化和进展性多发性硬化之间CP体积数据的比较.
主要成果:
- 增加的CP/TIV比率与较高的病变负载,正常出现的白质和体中TSPO吸收,以及在活跃的RRMS中增加复发率和残疾有关.
- CP/TIV比率与MRI定义的缩和EDSS分数在渐进性MS中存在弱相关性.
- 即使在正式诊断MS之前,也观察到CP扩大.
结论:
- 在早期的多发性硬化 (CIS,RIS,RRMS) 阶段,状体体积测定最为重要.
- 由于与疾病指标的相关性有限,在进展性多发性硬化症中应谨慎解释CP体积分析.
- 需要进一步的研究,以充分阐明CP在MS病原和进展中的作用.
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