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通过使用便携式呼吸分析仪进行呼吸测试来诊断结肠直肠癌-初步数据
Arcangelo Picciariello1, Agnese Dezi2, Leonardo Vincenti3
1Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Sensors (Basel, Switzerland)
|April 13, 2024
概括
使用挥发性有机化合物 (VOC) 的新型呼吸试验显示出对非侵入性结肠直肠癌 (CRC) 查的希望. 这种呼吸活检方法在区分CRC患者和健康个体方面取得了很高的准确性.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 分析化学 分析化学
背景情况:
- 目前的结肠直肠癌 (CRC) 查方法的可靠性和患者遵守性都很低.
- 呼出的气息中的挥发性有机化合物 (VOC) 为CRC检测提供了潜在的非侵入性生物标志物.
研究的目的:
- 通过呼吸分析评估便携式微气色谱仪设备的可靠性,以快速地在现场通过呼吸分析进行CRC诊断.
- 确定VOC生物标志物,以区分CRC患者与健康对照 (HC).
主要方法:
- 预期试验涉及从CRC患者和HC在转诊中心收集呼吸样本.
- 使用自动化的便携式气相色谱装置分析呼吸样本.
- 机器学习和统计方法 (LDA,PCA) 来识别有区别的VOC.
主要成果:
- 这项研究招募了68名受试者 (36名CRC,32名HC).
- 基于三种VOC,该设备在识别CRC患者时实现了87.5%的特异性,94.4%的灵敏性和91.2%的准确性.
- 高诊断性能在单独的培训和测试套件上得到了验证.
结论:
- 使用VOC分析的呼吸活检是检测CRC的一个有希望的非侵入性工具.
- 这种便携式设备可以在现场进行快速诊断,并有可能提高查遵守率.
- 进一步验证是有必要的,以建立呼吸分析作为标准的CRC查方式.
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