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低ALT与IBD和疾病活动有关:来自全国研究的结果
Asher Shafrir1,2,3, Lior H Katz2,3, Michal Shauly-Aharonov4,5
1Meuhedet Health Medical Organization, Jerusalem District, Tel Aviv 6203854, Israel.
Journal of clinical medicine
|April 13, 2024
概括
低氨酸转氨酶 (ALT) 在炎症性肠病 (IBD) 患者中更为普遍,并且与疾病活性标志物相关. 这一发现表明ALT可能有助于识别有活跃疾病的IBD患者.
科学领域:
- 胃肠病学 胃肠病学
- 生物化学 生物化学
- 内部医学 内部医学
背景情况:
- 在炎症性肠道疾病 (IBD) 患者中,萨科佩尼亚的诊断往往不足.
- 低氨酸转胺酶 (ALT) 水平与肉症有关.
- 这项研究调查了低ALT和IBD存在和活性之间的联系.
研究的目的:
- 为了确定低ALT和IBD存在之间的关联.
- 评估低ALT和IBD疾病活动之间的关系.
- 评估低ALT作为IBD中肉症的潜在指标.
主要方法:
- 分析了一大批以色列国家医疗保险公司队列 (976,615名患者).
- 将IBD患者与健康对照进行比较,不包括肝病患者,ALT升高 (>40 IU/L) 或18岁以下患者.
- 低ALT定义为<10 IU/L;数据分析使用多变量回归和倾向得分匹配.
主要成果:
- 低ALT在IBD患者 (7.76%) 中明显比对照组 (5.7%) 更常见.
- 在克罗恩氏病 (CD) 和性结肠炎 (UC) 中,低ALT与便中calprotectin和CRP的增加以及白蛋白和血红蛋白的降低相关.
- 经过调整以考虑混因素后,这些关联仍然很重要.
结论:
- 低ALT在IBD患者中更为普遍.
- 低ALT与IBD疾病活动的生化标志物有关.
- 低ALT可以作为管理IBD患者的有用指标,可能与肉症有关.
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