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复发的中东区分甲状腺癌比持久性疾病更糟糕的结果
Sandeep Kumar Parvathareddy1, Abdul K Siraj1, Padmanaban Annaiyappanaidu1
1Human Cancer Genomic Research, Research Centre King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
中东患者的复发性差异化甲状腺癌 (DTC) 与持久性疾病一样常见,但结果更糟. 区分这些疾病对于定制治疗和改善患者存活率至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 差异化甲状腺癌 (DTC) 的预后很好,但持续性和复发性疾病带来了重大的临床挑战.
- 区分复发性和持久性DTC的研究是有限的,特别是在中东人口中.
研究的目的:
- 调查中东群体中持续性与复发性DTC的患病率和临床特征.
- 确定复发性和持续性DTC的预测因子及其对患者结果的影响.
主要方法:
- 对1691名经过手术和/或I131治疗的DTC患者的回顾性分析.
- 随访时间中位数为95.3个月,分析了患者人口统计,瘤特征和生存数据.
主要成果:
- 观察到持久性 (17.7%) 和复发性 (17.9%) DTC 的流行率相似.
- 复发性DTC患者年龄较大,患高风险瘤的可能性更高,与持续性DTC患者相比,癌症特异性存活率更差.
- T和N状态是复发性和持续性疾病的独立预测因素,而年龄较大,双边性和甲状腺外延伸仅预测了复发性疾病.
结论:
- 中东患者的复发性DTC,尽管与持久性疾病的频率相似,但与较差的结果有关.
- 区分复发性和持续性DTC对于优化治疗策略和后续治疗具有临床意义,可能改善中东DTC患者的治疗结果.
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