埃洛尼德鼻腔皮质类固醇在治疗过敏性鼻炎的有效性:一项随机双盲试验
Hardip S Gendeh1,2, Aneeza W Hamizan1,2, Salina Husain1,2
1Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Journal of clinical medicine
|April 13, 2024
概括
埃洛尼德鼻喷剂在过敏性鼻炎中表现出与纳索内克斯 (Nasonex®) 不逊色的疗效,显著改善了鼻腔抵抗和生活质量. 这项研究证实,Elonide是一种安全且耐受性良好的治疗选择,副作用较少.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏学 过敏学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过敏性鼻炎 (AR) 显著影响生活质量.
- 莫马塔松酸鼻喷雾是一种常见的治疗AR症状.
- 对Elonide等新配方与已知治疗方法进行评估至关重要.
研究的目的:
- 为了比较Elonide与Nasonex®和安慰剂在AR成年人中的疗效.
- 评估Elonide的安全性和副作用概况.
- 为了确定Elonide是否与Nasonex®不劣.
主要方法:
- 一个前性的,单中心的,双盲的,随机的,安慰剂控制的非劣等性试验.
- 163名参与者被随机分配到三个组:Elonide,Nasonex®或安慰剂,持续4周.
- 主要结局:全鼻电阻 (TNR);次要结局:视觉模拟得分 (VAS) 和犀牛结膜炎生活质量调查问卷 (RQOLQ).
主要成果:
- 所有组都显示出与基线相比显著改善.
- 与安慰剂相比,Elonide在TNR,VAS和RQOLQ中显示出更高的平均差异 (p < 0.05).
- 埃洛尼德与Nasonex® (p = 1.00) 不逊色,并且副作用发生率最低 (12%).
结论:
- 埃洛尼德在治疗成人过敏性鼻炎方面表现出与纳索内克斯 (Nasonex®) 相似的疗效.
- 埃洛尼德是一种安全且耐受良好的治疗选择.
- 与Nasonex®和安慰剂相比,Elonide具有有利的副作用概况.
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