一个前性观察性研究关于胃内镜下粘膜解剖在持续给予抗血栓剂的情况下
Daisuke Kawai1, Masaya Iwamuro2, Ryuta Takenaka1
1Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
Journal of clinical medicine
|April 13, 2024
概括
在胃内镜下粘膜切割 (ESD) 期间持续的抗血栓治疗没有影响切割率,但显著增加了术后出血风险,特别是与丁二类药物.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 在瘤学瘤学.
背景情况:
- 内镜下粘膜切割 (ESD) 是胃瘤的关键治疗方法.
- 在持续的抗血栓治疗下进行ESD的安全性需要评估.
研究的目的:
- 评估连续抗血栓治疗患者的胃ESD完成率和术后出血发生率.
主要方法:
- 对88名接受胃ESD和持续抗血栓治疗的患者进行前性观察性研究.
- 与479名患者的回顾性数据进行比较,这些患者在没有抗血栓治疗的情况下接受了胃ESD.
主要成果:
- 群体之间高且可比的整体切除率 (100%) 和完全切除率 (97.0%对96.3%).
- 在抗血栓治疗组中,术后出血发生率显著增加 (10.2%对4.2%).
- 提伊诺皮里丁的使用与增加出血风险有关.
结论:
- 持续的抗血栓治疗会增加ESD后出血的风险,特别是与烯胺类药物.
- 在胃ESD之前,仔细管理抗血栓剂至关重要.
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