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在类风湿性关节炎中重新利用纤维化-4评分:ESPOIR队列数据

Renaud Felten¹, Thibaut Fabacher², Nathanaël Sedmak²

¹National Reference Center for Rare Auto-Immune Diseasesest Sud-Ouest (RESO), Department of Rheumatology, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France.

Journal of clinical medicine

|April 13, 2024

概括

纤维化-4 (FIB-4) 评分似乎不是类风湿性关节炎 (RA) 进展或结果的可靠预后因素. 这项研究没有发现FIB-4评分与RA患者10年内疾病活性,关节损伤或心血管事件之间的关联.

科学领域:

类风湿病学类风湿病学
肝病学肝病学是一种肝病学.
生物统计学生物统计学

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,需要预后标志物.
通常用于肝纤维化,纤维化-4 (FIB-4) 评分被评估为其在RA的预后价值.
预期ESPOIR队列为本次调查提供了数据.

研究的目的:

评估风湿性关节炎患者FIB-4评分的预后意义.
为了确定FIB-4评分是否预测RA的疾病进展,结构损伤或不良事件.

主要方法:

一项前性队列研究,包括647名符合ACR/EULAR标准的RA患者.
使用年龄,AST,ALT和血小板计数计算FIB-4得分.
线性混合效应模型分析了超过10年的重复测量.

主要成果:

FIB-4评分与10年疾病活动评分的进展没有独立相关.
基线FIB-4分数与5年后修改的夏普分数没有相关性.
FIB-4评分没有显示与死亡率或主要心血管不良事件的相关性.

结论:

在风湿性关节炎中,FIB-4评分缺乏预后价值.
随着时间的推移,FIB-4得分保持稳定,并没有因DMARD治疗而升高.
进一步的研究可能会探索RA预后的其他非侵入性标志物.

关键词:

在FIB-4中,FIB-4是第一个被指控的.这种疾病是共患的.预后因素是一个预后因素.类风湿性关节炎类风湿性关节炎

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