基于症状和功能障碍的长期COVID临床严重性类型:纵向评估
Manoj Sivan1,2,3, Adam B Smith4,5, Thomas Osborne1
1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS7 4SA, UK.
Journal of clinical medicine
|April 13, 2024
概括
长期COVID (LC) 严重程度类型随着时间的推移而保持一致,很大一部分患者在轻度,中度和严重类别之间切换,突出了这种疾病的波动性.
科学领域:
- 医学研究 医学研究
- 临床研究 临床研究
- 纵向分析是一种纵向分析.
背景情况:
- 长期COVID (LC) 是一种复杂的多系统状况,影响整体健康并导致功能障碍.
- 目前对LC临床严重程度类型的研究主要依赖于横截面数据.
- 了解LC严重程度的时间模式对于患者管理至关重要.
研究的目的:
- 为了研究长期COVID (LC) 临床严重程度类型的模式和一致性.
- 使用前样本分析LC严重性的纵向变化.
- 在长期COVID患者中识别不同的临床严重性集群.
主要方法:
- 涉及长期COVID患者的前性队列研究.
- 在两个时间点使用C19-YRSm (约克郡康复量表修改版) 结果测量.
- 在每个评估中使用k-means集群分析来定义临床严重性类型.
主要成果:
- 对759名患者的分析揭示了三种不同的LC临床严重程度类型:轻度,中度和严重.
- 来自356名患者的纵向数据显示了这些三种严重程度类型随着时间的推移的一致模式.
- 大约51%的患者在评估之间在临床严重程度类型之间进行过渡.
结论:
- 这项研究提供了第一个证据,证明了长期COVID临床严重程度类型随着时间的推移而形成的一致模式.
- 这些发现表明长期COVID的性质波动,患者在严重程度类别之间移动.
- 这些见解对于开发长期COVID患者的动态管理策略至关重要.
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