系统性红斑狼和代谢综合征中的生物标志物
Fernanda Isadora Corona-Meraz1,2, Mónica Vázquez-Del Mercado2,3,4, Flavio Sandoval-García2,4
1Multidisciplinary Health Research Center, Department of Biomedical Sciences, University Center of Tonala, University of Guadalajara, Guadalajara 45425, Jalisco, Mexico.
Journal of clinical medicine
|April 13, 2024
概括
代谢综合征 (MetS) 和系统性红斑狼 (SLE) 具有共同的生物标志物. 识别这些代谢和免疫标记可以改善早期诊断和预测患者两种疾病的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 代谢综合征 (MetS) 涉及肥胖,胰岛素抵抗 (IR) 和高甘油三血,增加心血管疾病 (CVD) 和2型糖尿病 (T2D) 的风险.
- 在MetS中免疫和代谢失调与自身免疫性疾病有关.
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,患有MetS和相关心血管疾病的患病率很高.
研究的目的:
- 审查MetS和SLE的主要生物标志物.
- 提出评估,以改善METS和SLE患者的诊断和预后.
- 在这些条件下探索代谢和免疫变化之间的联系.
主要方法:
- 对代谢概况,细胞因子,心血管测试和microRNAs (miRs) 的文献综述.
- 在患有MetS和SLE的患者中分析失调的生物标志物.
- 生物标志物与患者结果和疾病进展的关联.
主要成果:
- 代谢概况,细胞因子,心血管测试和微RNA (miRs) 被确定为关键生物标志物.
- 这些生物标志物在MetS和SLE患者中显示出失调.
- 生物标志物失调与疾病结果相关.
结论:
- 生物标志物识别对于早期诊断和改善METS和SLE患者管理至关重要.
- 建议进行综合性评估,包括代谢,免疫和心血管标志物.
- 对这些生物标志物的进一步研究可以提高诊断和预后能力.
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