白细胞葡萄糖指数升高与透析患者的长期动脉静脉失败有关
Adrian Vasile Mureșan1,2, Elena Florea2, Emil-Marian Arbănași1,2,3,4
1Department of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
Journal of clinical medicine
|April 13, 2024
概括
高白细胞葡萄糖指数 (LGI) 值预测动脉静脉 (AVF) 在末期病患者的失败. 这种生物标志物表明血管接入功能障碍的风险更高,独立于其他因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 血管外科 血管外科
- 生物标志物 生物标志物
背景情况:
- 动脉静脉 (AVF) 是最终阶段病 (ESKD) 患者透析的首选血管接入方式.
- 由于各种风险因素和并发症,一年内AVF的初级通病率低于70%.
- 白血球葡萄糖指数 (LGI) 是一种新的生物标志物,已经显示出与不良心血管结果的关联.
研究的目的:
- 研究手术前白细胞葡萄糖指数 (LGI) 对ESKD患者AVF长期初级通透性的影响.
- 为了确定LGI是否可以作为AVF衰竭的预测生物标志物.
主要方法:
- 对158名ESKD患者进行了回顾性观察性研究,这些患者接受了透析的AVF创建.
- 主要终点:AVF衰竭,定义为由于缩或血栓形成而无法进行慢性透析.
- 分析包括ROC分析和Kaplan-Meier生存分析,以评估LGI的预测价值.
主要成果:
- 患有AVF衰竭的患者表现出更高的LGI值 (1.12对0.79,p<0.001) 和心房动和糖尿病的患病率增加.
- LGI与AVF衰竭有很强的关联 (AUC = 0.729),最佳切断值为0.95.
- 较高的LGI三位数和基线LGI值与AVF衰竭的风险增加显著相关,独立于其他临床因素.
结论:
- 术前LGI升高是ESKD患者长期AVF衰竭的显著积极预测指标.
- 对于AVF衰竭,LGI的预后值独立于年龄,性别,心血管风险因素和血管映射.
- LGI可能是一个有价值的生物标志物,用于识别患有AVF功能障碍高风险的患者.
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