预测帕金森病中的抑郁症使用常用的PD问卷
Emanuele Camerucci1, Kelly E Lyons1, Rajesh Pahwa1
1Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Journal of clinical medicine
|April 13, 2024
概括
抑郁症在帕金森病 (PD) 患者中很常见,并且与更糟糕的运动和非运动症状有关. 定期评估至关重要,因为它经常被忽视和治疗不足.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 运动障碍 运动障碍
背景情况:
- 抑郁症是帕金森病 (PD) 的常见并发症,严重影响患者和护理人员的福祉.
- 抑郁症和PD中各种症状评估之间的相互作用需要进行彻底的调查.
研究的目的:
- 评估抑郁症严重程度与常用的PD患者问卷之间的关联.
- 确定抑郁症与PD中的运动,非运动,认知和生活质量症状之间的关系.
主要方法:
- 1214名PD患者被分为没有抑郁症,轻度和中度至重度的抑郁症组,使用老年抑郁症量表 (GDS).
- 收集的数据包括统一的PD评级量表 (UPDRS),蒙特利尔认知评估 (MoCA),爱普沃思睡眠量表 (ESS),非运动症状量表 (NMSS),PD生活质量 (PDQ-39),Hoehn和Yahr (H&Y) 评分,莱沃多巴每日相当剂量 (LEDD) 和抗抑郁药的使用.
主要成果:
- 抑郁症得分增加与运动症状 (UPDRS,H&Y),非运动症状 (NMSS),认知 (MoCA),嗜睡 (ESS) 和生活质量 (PDQ-39) 的恶化相关 (所有p < 0.001).
- 只有50%的轻度至重度抑郁症患者接受抗抑郁药;随着抑郁症的严重程度而增加LEDD.
- 在NMSS或PDQ-39分数中增加1个点,抑郁症风险分别增加16%和5%.
结论:
- 在PD中,抑郁症经常被诊断不足和治疗不足.
- 建议定期对PD患者进行抑郁症查,特别是那些运动或非运动症状正在演变的患者.
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