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德里斯比率预测中等和高风险肺栓塞的临床结果

Koray Durak¹, Katharina Nubbemeyer¹, Rashad Zayat¹

¹Department of Thoracic Surgery, Faculty of Medicine, RWTH University Hospital, 52074 Aachen, Germany.

Journal of clinical medicine

|April 13, 2024

概括

阿斯巴酸胺酶/阿氨酸胺酶 (AST/ALT) 的比率可以预测肺栓塞 (PE) 患者的结果. 异常的AST/ALT比率 (>1) 与更高的PE死亡率和并发症有关,表明其预后价值.

科学领域:

心脏病学心脏病学
肝病学肝病学是一种肝病学.
关键护理医学关键护理医学

背景情况:

异常的肝功能测试可以表明严重的心肺衰竭.
AST/ALT比率 (De Ritis比率) 评估肝损伤,但其在PE的预后作用尚不清楚.
肺栓塞 (PE) 是一种严重的疾病,需要准确的预后标志物.

研究的目的:

调查中期和高风险PE患者的基线AST/ALT比率的预后值.
确定异常的AST/ALT比率是否预测PE中的死亡率和其他不良结果.
评估AST/ALT比率与PE中的关键临床标志物之间的关联.

主要方法:

对两组中等和高风险PE患者的回顾性分析.
基于基线AST/ALT比率的分层:异常 (>1) 与正常 (<1).
逆概率加权 (IPW) 分析,以评估异常的AST/ALT比对结果的影响,包括60天死亡率和高峰NT-proBNP水平.

主要成果:

在230名患者中,52名 (23%) 患有异常的AST/ALT比.
IPW分析显示,在异常AST/ALT比率的患者中,60天死亡率显著增加,NT-proBNP水平达到峰值.
异常的AST/ALT比率与增加的休克风险,需要异型药物/血管压缩剂,机械通风和体外生命支持有关.

结论:

基线AST/ALT比率是PE患者不良结果的重要预测指标.
异常的AST/ALT比率与增加的休克风险,多器官衰竭和PE死亡率有关.
德里蒂斯比率为治疗肺栓塞患者提供了有价值的预后信息.

关键词:

利率降低利率降低利率降低心脏衰竭是因为心脏衰竭.重症监护医学的重症监护医学的医学.肝功能肝功能肝功能肺栓塞是肺肺栓塞的原因之一.肺栓塞肺栓塞是一种肺栓塞.冲击冲击冲击冲击冲击冲击转氨基酶是一种转氨基酶

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