使用蓝光囊镜检测膀癌检测率的种族差异:来自多中心注册表的见解
Seyedeh-Sanam Ladi-Seyedian1, Alireza Ghoreifi1, Badrinath Konety2
1Department of Urology, Norris Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Cancers
|April 13, 2024
概括
蓝光囊镜 (BLC) 改善了所有种族的膀癌检测. 这种增强的可视化技术与白光囊镜 (WLC) 结合使用时,可提高恶性病变识别率,特别是在亚洲患者中.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 蓝光囊镜 (BLC) 增强了膀瘤的可视化.
- 有限的数据存在于BLC在不同种族群体的有效性.
- 评估BLC表现中的种族差异对于公平的癌症检测至关重要.
研究的目的:
- 评估蓝光囊泡镜 (BLC) 性能在不同种族检测恶性膀病变方面的异质性.
- 在不同患者群体中,将BLC与白光囊泡镜 (WLC) 相结合的诊断准确性与单独的WLC进行比较.
主要方法:
- 来自多机构Cysview注册表 (2014-2021) 数据的回顾性分析.
- 包括接受过尿道切除或为膀瘤进行活检的患者.
- 对BLC和WLC跨种族群体 (高加索人,非裔美国人,亚洲人,西班牙裔) 的敏感性,正预测值 (PPV) 和负预测值 (NPV) 的评估.
主要成果:
- 在总队列和高加索和亚洲亚组中,BLC表现出比WLC更高的敏感性.
- 结合BLC和WLC,恶性病变的检测率总体增加了10%,亚洲患者的检测率增加了18%.
- 亚洲患者的PPV (94%) 与BCC最高,而西班牙裔患者的NPV最高 (86%).
结论:
- 蓝光囊镜 (BLC),当与白光囊镜 (WLC) 一起使用时,在所有研究的种族群体中显著提高了膀癌检测率.
- BLC为识别恶性病变提供了有价值的增强,在特定的种族子组中观察到显著的改善.
- 这些发现支持BLC的更广泛实施,以提高膀癌查和诊断的诊断准确度,而不论患者的种族.
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