消防员明显的前列腺癌生存结果:基于人口的研究
Paulo S Pinheiro1,2, Tulay Koru-Sengul1,2, Wei Zhao2
1Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Cancers
|April 13, 2024
概括
消防员表现出更好的前列腺癌生存率,特别是在局部化阶段,可能是由于增加了PSA测试. 然而,患有晚期癌症的老年消防员面临更高的死亡风险. 需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
背景情况:
- 在特定职业群体中,定期接受医疗检查的前列腺癌存活率尚未得到充分研究.
- 消防员接受严格的医疗评估,并暴露在潜在的致癌物质中,但他们的前列腺癌存活率仍然未经检查.
研究的目的:
- 调查和比较佛罗里达州消防员和普通人口之间的前列腺癌生存结果.
- 确定导致生存差异的因素,包括诊断时的年龄,癌症阶段和治疗方式.
主要方法:
- 使用佛罗里达癌症数据系统 (2004-2014) 和消防员认证记录进行的回顾性研究.
- 在消防员中比较了1058例前列腺癌病例和一般人口中的150,623例前列腺癌病例之间的特定原因生存率.
- 使用了根据人口统计,PSA水平,格里森得分和治疗进行调整的考克斯回归模型.
主要成果:
- 消防员的5年因特定原因生存率 (96.1%) 比一般人口 (94.2%) 高.
- 消防员被诊断年轻,有更多局部癌症 (84.7%) 和更高的手术利用率 (46.4%).
- 消防员在局部阶段 (aHR=0.53) 显示出生存优势,但在区域/远程阶段的老年消防员 (≥65) 死亡风险更高 (aHR=1.84).
结论:
- 消防员表现出更好的前列腺癌生存率,特别是局部疾病,可能与增加的PSA查有关.
- 与普通人群相比,晚期前列腺癌的老年消防员面临着较差的生存结果.
- 需要进一步的研究,以了解超出PSA/格里森得分的侵袭性疾病因素以及手术治疗对生活质量的影响.
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