2004年至2018年的黑色素瘤生存率改善的基于性别的差异
Vikram R Shaw1, Angela Hudock2, Baoyi Zhang3
1Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Cancers
|April 13, 2024
概括
黑色素瘤的生存率总体上有所改善,但人口群体之间仍然存在差异. 最近的诊断显示出更好的结果,但特定的子组在2004年至2018年之间生存率的改善较少.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 黑色素瘤是最致命的皮肤癌,发病率和死亡率因人口统计学而异.
- 很少有研究详细说明了黑色素瘤在性别,年龄,种族和社会经济地位方面的生存改善差异.
研究的目的:
- 描述不同人口群体黑色素瘤患者的生存改善差异.
- 分析基于性别的黑色素瘤生存差异,考虑种族和年龄.
- 调查高风险瘤在位 (CIS) 进展为黑色素瘤的生存结果.
主要方法:
- 利用了监测,流行病学和最终结果 (SEER) 数据库从2004年至2018年的生存数据.
- 对癌症特异性生存率 (CSS) 和基于性别的差异进行了多变量考克斯回归.
- 对高风险CIS至黑色素瘤病例进行了进展时间和生存分析.
主要成果:
- 2014-2018年对黑色素瘤诊断观察到改善的CSS与2004-2008年对两性进行比较.
- 白人和西班牙裔患者的生存改善趋势一致,但对于黑人和亚洲患者来说并不显著.
- 高风险的CIS进展为黑色素瘤,男性的CSS比女性更差.
结论:
- 从2004年到2018年,黑色素瘤的生存率普遍有所改善,特别是在最近的诊断中.
- 在某些人口亚组中,生存率改善的显著差异仍然存在.
- 需要进一步的研究来解决这些在黑色素瘤治疗和结果中发现的生存差距.
相关概念视频
01:21Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
01:20Comparing the Survival Analysis of Two or More Groups
179
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
179
01:30Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K