降低风险的乳房切除术和降低风险的卵管切除术的实用性评分:映射到EQ-5D
Samuel G Oxley1,2, Xia Wei1,3, Michail Sideris1,2
1Wolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Cancers
|April 13, 2024
概括
降低风险的乳房切除术和沙卵巢切除术显著影响生活质量. 这项研究为这些癌症预防程序提供了第一个与健康相关的实用性得分,对于患者咨询和经济评估至关重要.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 卫生经济学 卫生经济学
背景情况:
- 降低风险的乳腺切除术 (RRM) 和降低风险的卵管切除术 (RRSO) 是非常有效的癌症预防策略.
- 评估生活质量对于患者咨询和健康经济评估至关重要.
- 现有的文献缺乏发表的EQ-5D健康相关实用性得分 (HRUSs) 后RRM和后RRSO.
研究的目的:
- 通过使用EQ-5D来推导和呈现第一个与健康相关的实用性得分 (HRUS),用于接受降低风险的乳房切除术 (RRM) 和降低风险的卵管切除术 (RRSO) 的患者.
- 为为咨询患者的临床医生以及对这些癌症预防干预措施的健康经济评估提供必要的数据.
主要方法:
- 利用系统性审查的汇总数据,通过映射算法将SF-36/SF-12分数转换为EQ-5D HRUS.
- 采用随机效应元分析来计算调整后的不实用性和实用性得分.
- 进行了小组分析,比较长期与短期的随访结果.
主要成果:
- 降低风险的乳腺切除术 (RRM) 与长期的不实用性相关 -0.08 (95% CI -0.11, -0.04) 和 0.92.4 的实用性.
- 降低风险的卵管切除术 (RRSO) 与长期的无效率 -0.03 (95% CI -0.05,0.00) 和 0.97.9 的效用相关.
- 来自RRM的四项研究 (209名患者) 和RRSO的五项研究 (742名患者) 的数据.
结论:
- 本研究介绍了降低风险的乳腺切除术和卵管切除术后患者的首次与健康相关的实用性得分.
- 强调需要进行高质量的前性研究,以准确地描述这些程序后各个时间点的生活质量.
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