在患有低甲状腺症的甲状腺癌分化的患者中增加垂体-18-氧糖摄入量,而不是在复合人甲状腺刺激激素刺激下
Xinyi Shi1, Ilaria Giordani1, Marie Nicod Lalonde2
1Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Cancers
|April 13, 2024
概括
18F-FDG PET/CT 下垂体超新陈代谢在经过甲状腺激素戒断 (THW) 的差异化甲状腺癌患者中很常见. 应认识到这种对甲状腺功能低下的生理反应,以防止在成像评估期间误解.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 18F-FDG PET/CT用于评估差异化甲状腺癌 (DTC) 中的放射性非急性疾病.
- 在甲状腺激素戒断 (THW) 的DTC患者中,垂体18F-FDG摄入量升高可能表明甲状腺细胞因甲状腺功能低下而生理激活.
- 这项研究比较了在DTC患者中THW和复合人类TSH (rhTSH) 刺激之间的垂体18F-FDG吸收.
研究的目的:
- 为了比较使用THW与rHTSH刺激准备的DTC患者的垂体18F-FDG吸收.
- 调查在DTC患者THW期间观察到的垂体超代谢的生理基础.
主要方法:
- 对57名接受18F-FDG PET/CT (40 THW,17 rhTSH) 的DTC患者进行了回顾性分析.
- 使用最大标准化吸收值 (SUVmax) 和相对于小脑的SUVratio量化下垂体代谢.
- 在THW和rHTSH组之间对 pituitary代谢参数的统计比较.
主要成果:
- 在THW组 (62.5%) 与rhTSH组 (23.5%) (p=0.01) 相比, pituitaryhypermetabolism (SUVmax ≥4.1) 的患病率更高.
- 在THW组与rhTSH组相比,显著更高的垂体SUVmax和SUVratio (p<0.001两者).
- 仅在THW组中,血清TSH水平和垂体SUVmax/SUVratio之间存在正相关性 (r=0.41-0.44,p<0.01).
结论:
- 在接受THW的DTC患者中,18F-FDGPET/CT的垂体过度代谢是对甲状腺功能低下的常见生理反应.
- 了解这种生理现象对于准确解释18F-FDG PET/CT扫描在DTC管理中至关重要.
- 这一发现有助于避免在DTC患者下垂体病理的潜在误诊.
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