在分化甲状腺癌中探索BMI和侵略性组织病理亚型之间的联系 - - 来自多中心回顾性研究的见解
Giacomo Di Filippo1, Gian Luigi Canu2, Giovanni Lazzari1
1Endocrine Surgery Unit, Department of Surgery and Oncology, Verona University Hospital, 37134 Verona, Italy.
Cancers
|April 13, 2024
概括
肥胖和超重与皮肤状甲状腺癌 (PTC) 的攻击性亚型有关. 更高的身体质量指数 (BMI) 独立地预测PTC中的侵略性特征,影响瘤特征和风险类.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 肥胖和甲状腺癌,特别是侵袭性亚型之间的关联仍然不清楚.
- 分化甲状腺癌 (DTC) 包含各种组织学类型,预后不同.
研究的目的:
- 调查体质指数 (BMI) 和差异化甲状腺癌 (DTC) 的侵袭性病原学亚型 (AHS) 之间的关系.
- 确定BMI是否是特定DTC亚型中侵略性特征的独立预测因素.
主要方法:
- 在2020-2022年期间,对3868名为DTC进行了甲状腺切除术的患者进行了回顾性分析.
- 患者按BMI (正常体重不足,超重,肥胖) 分类,根据2022年世卫组织指南定义AHS.
- 使用统计分析,包括多变量分析,来评估BMI与临床病理特征之间的关联.
主要成果:
- 患有乳头甲状腺癌 (PTC) 的超重和肥胖患者表现出较高的AHS,双边/多焦点瘤和较大的结节转移率.
- 无论性别,BMI是PTC中AHS的独立预测因素.
- 在年轻的PTC患者中,BMI预测了更高的美国甲状腺协会 (ATA) 风险级别.
- 患有卵泡性甲状腺癌 (FTC) 的超重和肥胖患者的瘤较大,但对于FTC或赫特尔细胞癌 (HCC) 没有观察到与BMI相关的AHS差异.
结论:
- 超重和肥胖与皮质甲状腺癌中具有攻击性基因病理特征和临床病理特征的风险增加有关.
- 体重指数 (BMI) 是积极性PTC的重要独立预测指标,特别是在年轻人中.
- 进一步的研究可能会阐明具体的机制,将肥胖与甲状腺癌的攻击性联系起来.
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