在持久性HPV感染的妇女中,PAX1/JAM3甲基化和HPV病毒载量
Mingzhu Li1, Chao Zhao1, Xiaobo Zhang1
1Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing 100044, China.
Cancers
|April 13, 2024
概括
在持久性HPV感染中,PAX1/JAM3甲基化和HPV病毒载量升高. 更高的甲基化与更长的感染持续时间和更高的阴道病变风险相关,有助于早期检测宫癌前病变.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 需要进一步阐明PAX1/JAM3甲基化和HPV病毒载荷 (VL) 在没有高度宫病变的持续性HPV感染中的作用.
- 持续的HPV感染是宫癌前病变的危险因素.
研究的目的:
- 调查PAX1/JAM3甲基化和HPV VL与没有高度宫病变的女性持续性HPV感染的持续时间的相关性.
- 探索这些生物标志物在预测感染持续时间和并发病变方面的潜力.
主要方法:
- 实时PCR和生物完美复合实时 (BMRT) -HPV用于PAX1/JAM3甲基化和HPVVL的确定.
- 对231名患有持续性HPV感染且没有高度宫病变的女性进行分析,按感染持续时间 (<3年 vs. >3年) 分类.
主要成果:
- 患有HPV感染超过3年的个体年龄较大 (48.9岁与45.1岁相比),JAM3和PAX1甲基化水平显著更高 (p <0.05).
- 在PAX1和JAM3甲基化之间发现了显著的相关性 (p < 0.001),表明了感染持续时间的累积证据.
- 在超过3年的感染组中观察到更高的阴道内皮层病变发病率,HPV VL表明并发的宫-阴道病变 (特别是非16/18基因型).
结论:
- 随着持续性HPV感染的持续时间,PAX1/JAM3甲基化水平会增加.
- PAX1/JAM3甲基化可以作为HPV感染持续时间在癌前病变的发展前的累积标记.
- 在持续的HPV感染中,HPV VL是并发性宫性阴道病变的潜在生物标志物.
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