相关实验视频
Updated: Jun 28, 2025
11:42
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
9.4K
转化方面在转移性乳腺癌中的转化方面
Elizve Nairoby Barrientos-Toro1, Qingqing Ding2, Maria Gabriela Raso1
1Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancers
|April 13, 2024
概括
转移性乳腺癌 (MpBC) 是一种罕见的,激进的乳腺癌亚型,主要是三阴性乳腺癌 (TNBC). 研究探索其独特的特征和瘤免疫微环境,以寻求新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 超塑性乳腺癌 (MpBC) 是一种罕见的,异质的侵袭性乳腺癌.
- MpBCs主要是三阴性乳腺癌 (TNBCs),其特点是具有侵略性行为,化学抵抗性和较低的生存率,与其他TNBCs相比.
研究的目的:
- 综述和总结有关转移性乳腺癌的当前知识.
- 探索转化方面和治疗策略,专注于瘤免疫微环境.
主要方法:
- 对MpBC现有文献的审查.
- 分析组织学分类和分子特征.
- 在MpBC中探索上皮层-介质细胞过渡 (EMT).
主要成果:
- MpBC表现出不同的组织学亚型,其中大多数是高等级的.
- 表皮-介质细胞过渡 (EMT) 是一个关键特征,涉及表皮标记物的损失和介质细胞特征的增加,导致侵入性增加.
- MpBCs对新辅助化疗反应较差,生存率较低.
结论:
- 由于其具有攻击性和耐治疗性,MPBC存在重大临床挑战.
- 了解MpBC中的瘤免疫微环境和EMT对于开发有效的治疗干预措施至关重要.
相关概念视频
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K