酸盐及其水溶性衍生物对抗氧化活性的影响
Zhihua Wang1, Yongbin Yan2, Zhengmao Zhang1
1Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, Xiaogan 432000, China.
Polymers
|April 13, 2024
概括
酸盐及其衍生物具有显著的抗氧化特性,有效地清除自由基,并在体内改善抗氧化酶活性. 酸 (HPCS) 和酸的四级氨盐 (HACC) 与酸 (CS) 相比,显示出优越的抗氧化能力.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 素 (CS) 是一种具有潜在生物活性的天然多糖.
- 开发有效的抗氧化剂对于对抗氧化应激至关重要.
- 溶于水的基托桑衍生物可能会提高生物利用性和疗效.
研究的目的:
- 为了比较分析基托及其水溶性衍生物的体外和体内抗氧化活性.
- 研究作为抗氧化剂的奇托衍生物的结构-活性关系.
主要方法:
- 在体外抗氧化剂测定:DPPH激素清除,超氧化激素清除,基激素清除和降低能力.
- 活体研究:口服基托和衍生品,以评估血清中的脂质过氧化物 (LPO),自由脂肪酸 (FFA) 和超氧化物脱酶 (SOD) 活性.
- 统计分析以确定显著差异 (p < 0.05).
主要成果:
- 所有测试的素样本都表现出自由基清除和减少能力.
- 酸 (HPCS) 和酸的四级氨盐 (HACC) 与酸 (CS) 相比显示出显著更高的抗氧化活性.
- 在体内,奇托和衍生物降低了LPO和FFA水平,同时增加了SOD活性,HPCS和HACC的显著影响.
结论:
- 素及其水溶性衍生物 (HPCS,HACC,CMCS) 具有显著的抗氧化特性.
- 抗氧化剂的有效性按照以下顺序进行:HPCS > HACC > CMCS > CS.
- 抗氧化剂活性依赖于度,并可能与奇托衍生物的分子结构有关.
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