非织造增强光固化聚 ((糖脂酸盐)) 基水凝
Michael Phillips1, Giuseppe Tronci1, Christopher M Pask2
1Clothworkers' Centre for Textile Materials Innovation for Healthcare, Leeds Institute of Textiles & Colour, School of Design, University of Leeds, Leeds LS2 9JT, UK.
Polymers
|April 13, 2024
概括
这项研究引入了一种新的聚合物复合物用于植入式水凝,增强机械强度和弹性. 纤维增强显著改善了用于组织再生应用的特性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 植入式水凝需要与周围组织匹配的机械特性,以便在再生过程中发挥最佳功能.
- 对于可降解,高含水量水凝在机械活性部位,如足部,实现这一目标是很困难的.
- 水凝复合材料提供了一种策略,可以随着时间的推移控制结构特征和宏观性质.
研究的目的:
- 为了合成一种新型的可光固化的弹性聚合物,poly ((glycerol-co-sebacic acid-co-lactic acid-co-polyethylene glycol) 烯酸盐 (PGSLPA).
- 在没有恶劣条件的情况下将PGSLPA加工成UV固化水凝,电无布和纤维增强复合材料.
- 研究微观结构和分层对这些可生物吸收的水凝复合材料的机械性能的影响.
主要方法:
- PGSLPA聚合物的合成.
- 制造紫外线固化水凝,电无布和纤维增强水凝复合材料.
- 机械测试 (压力强度,弹性,压力疲劳) 的水凝变体与或没有无强化和不同的层次.
主要成果:
- 与无纤维样本相比,非织物增强的PGSLPA水凝的压力强度增加了60%,弹性模块增加了80%.
- 通过改变无布和水凝相的分层安排,可以调整机械性能.
- 纳米纤维增强的水凝表现出良好的弹性恢复,在疲劳测试中显示出最小的歇斯底里.
结论:
- PGSLPA水凝复合材料,特别是带有无钢筋,提供了增强的机械性能,适合承载性组织工程应用.
- 这些复合材料的可调性性质允许根据特定的解剖部位要求量身定制的机械反应.
- 开发的材料为开发用于组织再生的先进植入式设备提供了一个有前途的平台.
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