牙阿拉伯语-可科利索姆矩阵的前景,以封装黄素用于口服
Dwi Hudiyanti1, Muhammad Fuad Al Khafiz2, Khairul Anam1
1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Prof. Jacob Rais Street, Semarang 50275, Central Java, Indonesia.
Polymers
|April 13, 2024
概括
这项研究开发了一种牙阿拉伯语-可可利索姆矩阵,以改善黄素的输送. 优化的配方增强了黄素的功效.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 黄素是一种强有力的抗氧化剂,由于溶解度低,其口服生物利用性较差.
- 脂质体为黄素等脂友性化合物提供了一个有前途的输送系统.
- 胆固醇和牙阿拉伯语 (GA) 可以稳定脂质体配方.
研究的目的:
- 为了将黄素封装在一个牙阿拉伯语-cocoliposome (CCL/GA) 矩阵中.
- 评估不同胆固醇 (Cchol) 和GA (CGA) 度对黄素封装和释放的影响.
- 在模拟的胃和肠液中评估封装的黄素的抗氧化活性和稳定性.
主要方法:
- 黄素被封装在一个CCL/GA矩阵中,具有不同的Cchol (0-40%) 和CGA (0-40%) 度.
- 福里埃变换红外光谱法 (FTIR) 用于确认非共价相互作用.
- 封装效率 (EE),负载能力 (LC),抗氧化活性 (IR) 和释放率 (RR) 在模拟的肠液 (SIF) 和模拟的胃液 (SGF) 中测量.
主要成果:
- 增加的Cchol增强了RR,但减少了EE,LC和IR.
- 增加的CGA改善了EE和IR,同时降低了LC和RR.
- 脂质体库尔库在SIF中显示了最高的IR (84.081%),在SGF中显示了最高的RR (0.657 ppm/day). 确定了SIF和SGF条件的最佳配方.
结论:
- CCL/GA矩阵有效封装黄素,配方成分显著影响其特性.
- 开发的脂质体黄素配方在模拟生理流体中表现出增强的稳定性和释放特征.
- 与模拟胃液相比,CCL/GA系统在模拟肠液中表现出优异的性能.
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