在胎儿巨囊中产前功能的产后功能决定因素:系统性审查
Ugo Maria Pierucci1, Irene Paraboschi2, Guglielmo Mantica3
1Department of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
Diagnostics (Basel, Switzerland)
|April 13, 2024
概括
使用胎儿成像和尿路生物标志物,可以预测先天性大囊的婴儿功能不佳. 这种系统性审查有助于临床医生为父母提供咨询,并确定产前干预的病例.
科学领域:
- 围产科和胎儿医学
- 儿科脏病学 儿科脏病学
- 医学成像和诊断 医学成像和诊断
背景情况:
- 先天性巨囊可能会导致婴儿产后功能不佳的风险.
- 准确预测结局对于适当的管理和家长咨询至关重要.
- 预测产后功能现有的方法需要进一步评估.
研究的目的:
- 评估人口统计数据,胎儿成像和尿分析物的临床实用性,以预测先天性巨囊症胎儿的出生后功能不佳.
- 为临床医生提供基于证据的预后工具,指导产前干预决策.
主要方法:
- 从开始到2023年12月,对MEDLINE电子数据库进行了系统审查.
- 关键词包括与下泌尿道阻塞,大囊,产前超声波,羊水,胎儿尿液生物标志物和功能结果相关的术语.
- 两个独立的评论员选择了评估产前成像和胎儿尿液分析物用于预测产后功能准确性的文章.
主要成果:
- 20篇文章,包括1049个胎儿,符合选择标准.
- 胎儿成像发现,如胎液状况和回生性等,显示出具有预测价值.
- 虽然大多数尿分析物具有有限的预后价值,但特定的尿路生化特征 (低,,度,β2-微型球蛋白,总蛋白) 和高的β2-微型球蛋白水平与分别具有不良和受损的产后功能有关.
结论:
- 人口统计数据,胎儿成像参数和特定的尿分析剂可以可靠地识别患有巨囊症的胎儿,这些胎儿有不良产后脏结果的风险.
- 这一系统性审查为临床医生提供了宝贵的见解,为父母提供有关婴儿预后的建议.
- 这些发现可以帮助选择适合产前干预的病例,可能改善长期脏健康.
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