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Updated: Jun 28, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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固相合成的安全捕获连接器

Sikabwe Noki1,2, Beatriz G de la Torre2, Fernando Albericio1,3

  • 1Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.

Molecules (Basel, Switzerland)
|April 13, 2024
PubMed
概括

安全捕获链接器通过允许同时使用 tert-butoxycarbonyl (Boc) 和 fluorenylmethoxycarbonyl (Fmoc) 保护组来增强固相合成 (SPPS). 这些链接器提供了多功能裂变选项,提高了合成效率.

关键词:
这就是为什么SPPS是SPPS.氧化性SCLss的使用情况保护群体保护群体降解酸解SCLs的SCLs的降解酸解.安全捕获链接器 (SCLs)

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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