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在癌症中具有抗血管生成功能的黄类药物

Qiang Wei¹, Yi-Han Zhang¹

¹School of Medicine, Anhui Xinhua University, 555 Wangjiang West Road, Hefei 230088, China.

Molecules (Basel, Switzerland)

|April 13, 2024

概括

来自植物的黄类化合物显示出作为癌症治疗的天然抗血管原剂的前景. 本综述探讨了它们的机制,针对关键信号通路,如HIF-1α/VEGF.

科学领域:

分子生物学分子生物学
药理学药理学是指药理学的学科.
植物生物化学植物生物化学

背景情况:

血管新生,新血管的形成,对于癌症的发展和进展至关重要.
目前的抗血管性疗法往往涉及昂贵或有毒的合成化合物和抗体.
迫切需要价格实惠,毒性较低,有效的抗血管生成剂.

研究的目的:

审查天然来源于植物的黄胺的抗血管性质.
阐明这些黄类药物通过哪些分子机制来发挥它们的抗血管效应.
总结黄酸的结构,分类,以及它们与植物信号通路的相互作用.

主要方法:

关于植物衍生性黄类药物及其抗血管生成活性研究的文献综述.
对分子机制的分析,重点关注参与血管生成的关键信号通路.
弗拉沃诺因子的结构-活性关系及其分类的概述.

主要成果:

自然衍生的黄类药物具有显著的抗血管新生潜力.
黄类药物调节关键信号通路,包括HIF-1α/VEGF/VEGFR2/PI3K/AKT,Wnt/β-catenin,JNK1/STAT3和MAPK/AP-1.
来自植物的黄类药物为合成抗血管原药提供了一个有希望的替代品.

结论:

植物衍生的黄类化合物是新型抗血管原性化合物的宝贵来源.
了解它们的分子机制为开发新的癌症疗法提供了基础.
需要进一步的研究来改善临床应用的黄类生物可用性.

关键词:

抗血管生成的作用癌症癌症癌症癌症癌症黄类化合物黄类化合物这是一个机制机制.植物植物植物植物植物植物.信号通道的信号通道.

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