奎诺亚多糖的物理化学特性和生物活动
Xucheng Zhu1, Guiyan Yang2, Yingbin Shen1
1School of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Molecules (Basel, Switzerland)
|April 13, 2024
概括
昆多糖 (Q-40,Q-60) 具有多种不同的生物功能. Q-60具有强烈的抗氧化和抗菌特性,而两者都根据度不同地影响癌细胞的增殖.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物化学 生化学
- 营养科学 营养科学
背景情况:
- 昆以其高营养价值而闻名,含有重要的多糖.
- 昆多糖的生物功能尚未得到充分了解.
- 这项研究调查了昆多糖提取物的特性和生物活性.
研究的目的:
- 描述两种原始昆多糖提取物 (Q-40和Q-60).
- 评估它们的抗氧化,抗菌和细胞毒性作用.
- 探索它们在食品工业中的潜在应用.
主要方法:
- 序列性乙醇沉以获得Q-40 (40%的乙醇) 和Q-60 (60%的乙醇).
- 高性能液体染色学 (HPLC) 用于纯度评估.
- 单糖体分析,分子量测定,风湿学实验,DPPH和ABTS激素清除试验,抗菌活性微稀释方法,细胞增殖试验 (MDA和HepG2细胞).
主要成果:
- Q-40和Q-60提取物的纯度分别为58.29%和62.15%.
- 单糖的组成和分子量范围在Q-40和Q-60之间有显著差异.
- Q-60表现出强大的抗氧化活性 (98.49%的DPPH清除) 和对MRSA的抗菌作用.
- Q-40抑制了MRSA和大肠杆菌的生长.
- 这两种多糖都对MDA和HepG2细胞增殖产生了双相作用,在低度下抑制,在高度下促进.
结论:
- 昆多糖具有独特的物理化学特性和生物活性.
- Q-60显示出显著的抗氧化和抗菌潜力,特别是对抗MRSA.
- 对细胞增殖的差异性影响需要进一步研究功能性食品的应用.
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