带有柏柏林化的半孔纳米颗粒的紫外线触发的药物释放:增强抗菌活性
Fanjiao Zuo1, Boyao Wang2, Lizhi Wang3
1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Molecules (Basel, Switzerland)
|April 13, 2024
概括
与紫外线敏感聚合物 (PEI) 功能化的半孔纳米粒子 (MTN) 有效地封装了抗菌药物柏柏林化 (BH). 这种新的BH@MTN-PEI系统展示了UV控制的BH释放和对大肠杆菌的显著抗菌活性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 抗生素耐药细菌对全球健康构成重大威胁.
- 半孔纳米颗粒 (MTN) 显示出对抗微生物应用的前景.
- 开发新的药物输送系统对于对抗耐药性感染至关重要.
研究的目的:
- 合成和表征与聚乙烯胺 (PEI) 功能化的对紫外线有反应的半孔纳米粒子 (MTN).
- 将柏柏林化物 (BH) 封装到MTN-PEI中,用于控制药物输送.
- 评估BH装载纳米颗粒对大肠杆菌 (E. coli) 的抗菌疗效.
主要方法:
- 通过MTN与PEI的功能化,合成MTN-PEI.
- 使用SEM,TEM,FT-IR,TGA,XRD,XPS和N2吸附-溶解的特性.
- BH的封装和药物负载和封装效率的评估.
- 研究UV控制的药物释放动力学.
- 确定抗菌活性,最小抑制度 (MIC) 和最小杀菌度 (MBC) 针对大肠杆菌.
主要成果:
- MTN-PEI具有较高的特定表面积 (238.43 m2/g),促进了高药物负载 (22.71 ± 1.12%) 和包装 (46.56 ± 0.52%) 的BH.
- 紫外线照射触发了纳米颗粒中BH的受控释放.
- BH@MTN-PEI表现出显著的紫外线依赖的抗菌活性,在8分钟的辐射后达到37.76%的细菌致死率.
- 对*大肠杆菌*的BH@MTN-PEI的MIC和MBC分别确定为1 mg/mL和5 mg/mL.
结论:
- 对紫外线敏感的MTN-PEI纳米颗粒是BH的有效载体,可控制药物释放.
- 开发的系统对大肠杆菌具有强大的抗菌作用,为抗生素耐药性提供了潜在的策略.
- 这项研究为使用纳米材料和外部刺激的先进抗微生物药物输送系统提供了概念验证.
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