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螺旋素类化合物的总合成的最新进展

Jing Hu1, Zhen-Xi Niu1, Jun-Feng Wang2

  • 1Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, China.

Molecules (Basel, Switzerland)
|April 13, 2024
PubMed
概括

来自Aspergillus fumigatus的螺旋性前列腺素类化合物显示出强大的抗癌活性. 本综述详细介绍了它们的合成,重点是构建用于药物开发的独特的螺旋环核.

关键词:
控制激烈度的控制方法螺旋-C 原子的原子螺旋性质前列腺素是什么总合成总合成

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Preparation of 1° Amines: Gabriel Synthesis01:28

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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