一项前性观察性研究分析了Hepcidin-25对炎症性肠病患者贫血的诊断价值
Stanko Petrović1,2, Dino Tarabar3, Danica Ćujić4
1Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia.
International journal of molecular sciences
|April 13, 2024
概括
肝素-25和费里丁水平表明炎症性肠病 (IBD) 患者的炎症和贫血严重程度. 较高的hepcidin-25与增加的费里和C反应蛋白 (CRP) 相相关,反映了活跃的疾病.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 贫血,包括缺铁性贫血 (IDA) 和慢性疾病贫血 (ACD),是炎症性肠病 (IBD) 的常见并发症.
- 治疗IBD贫血的治疗策略取决于疾病活性和贫血类型.
- 肝素-25,促炎细胞因子和血小板激活标志物是IBD中贫血和炎症的潜在生物标志物.
研究的目的:
- 评估肝素-25,促炎细胞因子和血小板激活标志物之间的关系,作为活性IBD和缓解中的贫血和炎症的生物标志物.
- 评估肝素-25,费里丁,C反应蛋白 (CRP) 和IBD患者的疾病活性之间的相关性.
主要方法:
- 一项前性观察性研究包括62名贫血IBD患者 (性结肠炎和克罗恩病) 和10名IBD患者在缓解期 (对照组).
- 根据疾病活动的内镜标志和贫血类型 (IDA或ACD) 将患者分类.
- 测量了CRP,血红蛋白,血清铁,铁素,肝素-25,介质蛋白,TNF-α,IFN-γ,可溶性CD40连接体和sP-选择素的水平.
主要成果:
- 肝素-25水平在患有活性IBD和ACD (II组) 的患者中明显高于患有IDA (I组) 的患者 (11.93vs4.48ng/mL,p<0.001).
- 第二组的费里丁和CRP水平也明显高于第一组 (费里丁:47.5比11.0ng/mL;CRP:13.68比3.39mg/L,p<0.001).
- 在活跃的IBD患者 (II组) 中,肝素-25与费里丁 (ρ = 0.725,p < 0.001) 和CRP (ρ = 0.502,p = 0.003) 有正相关性. 费里丁独立地影响了肝素-25水平.
结论:
- 肝素-25水平与费里丁和CRP相关,反映了IBD炎症和疾病活动的程度.
- 费里丁是IBD患者肝素-25度的独立预测剂,不论疾病活性或贫血严重程度.
- 肝素-25和费里丁作为评估IBD管理中的炎症和贫血的有价值的生物标志物.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Inflammatory Bowel Disease I: Ulcerative Colitis
173
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
173
Serum Laboratory Studies, Stool Test, Breath Test
343
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
343
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
116
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
116


