免疫细胞分解活性和治疗治疗策略
Stephanie Agioti1, Apostolos Zaravinos1,2
1Cancer Genetics, Genomics and Systems Biology Laboratory, Basic and Translational Cancer Research Center (BTCRC), 1516 Nicosia, Cyprus.
International journal of molecular sciences
|April 13, 2024
概括
内免疫细胞分解活性 (CYT) 是癌症免疫治疗成功的关键. 评估和调节CYT可以改善患者的预后和治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 内免疫细胞分解活性 (CYT) 对癌症免疫疗法的有效性至关重要.
- CYT受免疫检查点,瘤微环境 (TME),抗原呈现和新陈代谢的影响.
研究的目的:
- 审查评估CYT的方法.
- 讨论CYT调节的临床影响和治疗潜力.
主要方法:
- 瘤透淋巴细胞 (TILs) 的流动细胞计和免疫组织化学.
- 在TME中对CYT进行基因表达概况和空间分析 (多重体免疫光学,成像质细胞计) .
主要成果:
- 增加的CYT与积极的临床结果和有利的预后相关.
- CYT作为患者分层的预后生物标志物.
结论:
- 了解和调节CYT对于推进癌症免疫治疗至关重要.
- 向CYT提供了有希望的策略,以提高治疗反应和改善患者的治疗结果.
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