迪希德罗尔哥他胺增加了脑中的胺水平,并在斯科波胺诱导的失忆症模型中改善了记忆力
Maricarmen Hernández-Rodríguez1, Elvia Mera Jiménez1, María Inés Nicolás-Vázquez2
1Laboratorio de Cultivo Celular, Neurofarmacología y Conducta, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Ciudad de México 11340, Mexico.
International journal of molecular sciences
|April 13, 2024
概括
狄欧戈他胺 (DHE) 通过抑制组胺N-甲基转移酶 (HNMT) 来增加海马的组胺水平. 这种机制逆转了小鼠中斯科波拉胺诱导的记忆障碍,这表明DHE.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 增加组胺水平显示出治疗精神疾病中的记忆缺陷的前景.
- 美国食品和药物管理局批准的一种偏头痛药物 - - 狄尔戈他胺 (DHE) 抑制了组织胺N-甲基转移酶 (HNMT),这种酶会在大脑中禁用组织胺.
研究的目的:
- 调查DHE对海马皮组织胺水平和记忆功能的影响.
- 在斯科波拉胺诱导的记忆丧失模型中评估DHE的疗效.
- 确定组胺受体 (H1R和H2R) 在DHE增强记忆效应中的作用.
主要方法:
- 在DHE给药后,对大鼠的海马皮组织胺水平进行评估.
- 利用斯科波胺诱导的失忆模型与新型物体识别 (NOR) 和莫里斯水迷宫 (MWM) 行为测试.
- 研究了组胺受体对抗剂 (利胺) 对DHE增强记忆的作用.
主要成果:
- DHE (10 mg/kg) 剂量在1小时后显著增加海马体的基因组胺水平,但在5小时后并未显著增加.
- 在NOR和MWM范例中,DHE (1 mg/kg) 逆转了斯科波拉胺诱导的记忆障碍.
- DHE的增强记忆效应被H1R抗剂,利胺的预治疗所阻断.
结论:
- 在斯科波拉胺诱导的失忆症模型中,二欧戈他胺 (DHE) 增强记忆.
- DHE的促记忆效应是由海马体中 histamine 水平增加的介导.
- DHE充当HNMT抑制剂,导致基因组胺的升高和随后的记忆力改善.
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