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Cryptomphalus aspersa 蛋提取物保护人类干细胞免受压力诱导的过早衰老的影响

Zozo Outskouni¹, Christina Christodoulou¹, Andreas Goutas^1,2

¹Department of Biology, Faculty of Medicine, University of Thessaly, 41500 Larisa, Greece.

International journal of molecular sciences

|April 13, 2024

概括

克里普托姆法卢斯·阿斯珀萨蛋提取物 (CAEE) 增强了人体介质干细胞中的干细胞和抗氧化防御. 这种提取物可以通过调节自和防止压力诱导的过早衰老来提供抗衰老的好处.

科学领域:

生物遗传学生物遗传学
细胞生物学细胞生物学
皮肤病学皮肤病学

背景情况:

细胞衰老,一种不可逆转的增长停止状态,有助于衰老和与年龄相关的疾病.
自然衍生化合物因其潜在的抗衰老和抗氧化特性而受到越来越多的关注.

研究的目的:

为了研究Cryptomphalus aspersa蛋提取物 (CAEE) 的抗衰老和抗氧化作用.
评估CAEE对人类沃顿果介质干细胞 (WJ-MSCs) 的干细胞,伤口愈合,抗氧化防御和DNA修复的影响.

主要方法:

用CAEE处理WJ-MSCs的方法.
评估茎状性标记物和伤口愈合能力.
测量抗氧化分子 (GSH) 和调节剂 (NRF2).
分析压力诱导的过早衰老 (SIPS),自标志物,自细胞形成和Caveolin-1水平.

主要成果:

CAEE增强了WJ-MSC的干度,并可能提高了伤口愈合能力.
CAEE表现出显著的抗氧化能力,增加了GSH和NRF2水平.
CAEE减轻了氧化应激,通过诱导自和降低Caveolin-1水平来预防SIPS.

结论:

Cryptomphalus aspersa蛋提取物具有强大的抗氧化和抗衰老特性.
CAEE可能通过调节Caveolin-1-自-衰老分子轴来发挥其作用.
作为治疗与年龄有关的疾病的天然治疗剂,CAEE具有前景.

关键词:

介质细胞干细胞介质细胞干细胞营养保健品营养保健品衰老是一种老化.牛蛋提取物牛蛋提取物

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