生物活性化合物和桃茎提取物通过化品应用的潜在健康益处
Abigail García-Villegas1, Álvaro Fernández-Ochoa1, María Elena Alañón2,3
1Department of Analytical Chemistry, University of Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
International journal of molecular sciences
|April 13, 2024
概括
桃茎提取物富含抗氧化剂,通过对抗自由基和抑制皮肤损伤酶,显示出显著的抗衰老潜力. 在化品凝中配制,它在局部使用中表现出良好的稳定性.
科学领域:
- 自然产品化学 自然产品化学
- 化品科学 化品科学
- 皮肤病学 皮肤病学
背景情况:
- 桃茎含有多和酸,以抗氧化和抗炎性质而闻名.
- 这些化合物是传统上使用的,并且显示出治疗皮肤衰老和疾病的潜力.
研究的目的:
- 评估桃茎提取物用于护肤应用的抗氧化和抗炎作用.
- 描述提取物的化学成分,并评估其在抑制皮肤衰老酶方面的有效性.
主要方法:
- 高性能液体染色学-电子喷雾电离-四极飞行时间质谱学 (HPLC-ESI-qTOF-MS) 用于提取物表征.
- 检测总含量,抗氧化能力,激素清除活性和酶抑制 (HYALase,原酶,丁氧化酶).
- 将提取物制成化品凝和随后的稳定性测试 (加速和长期).
主要成果:
- 在桃茎提取物中发现了146种化合物.
- 提取物表现出强大的激素清除活性,对抗NO·和HOCl激素 (IC50值:2.32和5.4 mg/L).
- 观察到显著抑制HYALase,原酶和丁氧化酶 (XOD) 酶 (IC50值分别为7.39,111.92和10 mg/L).
- 含有桃茎提取物的化品凝配方显示出良好的稳定性和适用于局部应用的兼容性.
结论:
- 桃茎提取物具有显著的抗氧化和抗炎性质.
- 提取物有效地抑制了参与皮肤衰老的关键酶.
- 桃茎提取物是一个有前途的,稳定的成分,用于化品和护肤产品的开发.
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