单细胞和巨细胞在脏疾病和恒常状态中的作用
Rajesh Nachiappa Ganesh1,2, Gabriela Garcia3, Luan Truong1
1Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
International journal of molecular sciences
|April 13, 2024
概括
巨细胞是一种炎症细胞,在损伤和疾病中起着关键作用. 了解它们的功能,可以了解脏疾病的潜在新疗法和生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
背景情况:
- 单细胞-巨细胞系表现出显著的可塑性.
- 巨细胞具有M1和M2表型,具有双重的毒和保护作用.
- 巨细胞有助于各种脏疾病,包括丸炎,管管间隙和血管疾病.
研究的目的:
- 在脏疾病中审查巨细胞诱导的病原遗传机制.
- 要突出最新的发现巨细胞在不同病区的作用.
- 为了解细胞参与常见脏疾病的背景提供背景.
主要方法:
- 对病理学中巨细胞现有研究的文献综述.
- 关于巨细胞可塑性和表型 (M1/M2) 的信息综合.
- 分析巨细胞在免疫复合体和免疫性乳腺膜炎和其他损伤中的作用.
主要成果:
- 巨细胞是免疫复合体和免疫性脑膜炎中损伤的核心.
- 单细胞在自身免疫性病中导致急性损伤.
- 巨细胞涉及到管间和血管脏疾病,人类数据有限.
结论:
- 巨细胞是各种脏疾病的发病过程中的关键参与者.
- 了解巨细胞的作用可以导致新的治疗策略和预后生物标志物.
- 需要进一步的人类研究才能充分阐明巨细胞对病理学的贡献.
相关概念视频
Renal Corpuscle
2.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.0K
Introduction to Urinary System
2.5K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.5K
Nephrons
2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Kidney Structure
69.6K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.6K
Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K


