长期COVID中微质对神经可塑性和长期认知后果的影响:对大脑发育和超越的影响
Luana da Silva Chagas1,2,3, Claudio Alberto Serfaty1,2,3
1Program of Neuroscience, Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói 24210-201, Rio de Janeiro, Brazil.
International journal of molecular sciences
|April 13, 2024
概括
长期的COVID可能会通过破坏大脑免疫细胞 (微细胞) 来引起认知问题. 这会影响大脑发育,可塑性,并可能导致学习障碍和成人认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 微质细胞对大脑发育和健康至关重要,对压力因素作出反应,并塑造神经回路.
- 神经炎症是COVID-19病变发生的一个关键因素.
- 长期的COVID与认知缺陷有关,这表明与微质功能障碍的联系.
研究的目的:
- 探索将长期COVID与认知后续联系起来的分子机制.
- 了解微质失调如何影响长期COVID中的大脑可塑性.
主要方法:
- 关于长期COVID,神经炎症和微质功能的当前文献的审查.
- 对参与突触重塑和可塑性的分子通路的分析.
主要成果:
- 长期的COVID与降低的大脑衍生神经营养因子 (BDNF) 水平有关.
- 观察到免疫细胞和微质细胞之间的相互作用发生变化,炎症体,细胞因子和化学因子的增加.
- 信号通路的变化,如折素,补充系统,SIRPα/CD47和矩阵重塑,影响神经可塑性.
结论:
- 长期COVID中的微质失调有助于大脑可塑性受损.
- 这些机制是认知缺陷的基础,影响学习,神经发育和成人认知.
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