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Updated: Jun 28, 2025

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures

Published on: May 9, 2020

在男性和女性的全身性硬化症中不同的Kynurenine路径失调

Monika Turska-Kozłowska¹, Bruno Pedraz-Petrozzi², Piotr Paluszkiewicz³

¹Department of Molecular Biology, The John Paul II Catholic University of Lublin, Konstantynow 1H, 20-708 Lublin, Poland.

International journal of molecular sciences

|April 13, 2024

概括

系统性硬化症患者表现出改变的金氨酸通路 (KP) 代谢产物. 男人表现出较高的KP激活,而ACE抑制剂可能会影响SSc患者的KP代谢物水平.

科学领域:

免疫学免疫学免疫学
代谢学代谢学代谢学
自免疫性疾病自免疫性疾病

背景情况:

系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,具有显著的炎症成分.
参与三甲代谢的金氨酸 (KP) 途径在SSc病理生理学中未得到充分研究.
了解SSc的性别相关差异对于开发有针对性的疗法至关重要.

研究的目的:

在SSc患者中调查KP激活的性别特异性差异.
评估血管酶转化酶 (ACE) 抑制剂对SSc.中KP代谢物的影响.
评估估计的膜过率 (eGFR) 与SSc.中的KP代谢物之间的关系.

主要方法:

分析了48名SSc患者和53名健康对照者的血清样本.
高性能液体染色学量化了三聚烯 (TRP),金氨酸 (KYN) 和金酸 (KYNA).
使用多变量协变性分析 (MANCOVAs) 来比较组,控制年龄和BMI.

主要成果:

与对照组相比,男性和女性SSc患者的TRP下降,KYNA/TRP和KYN/TRP比率增加.
与对照组相比,SSc男性的KYN更高,KYNA/KYN比率下降,与女性不同.
用ACE抑制剂的患者血清KYNA较高;在SSc患者中,eGFR与KYNA水平有显著的相关性.

结论:

SSc患者表现出明显的KP变化,男性表现出更明显的激活.
ACE 抑制剂可能会调节 SSc 中的 KP,这需要进一步研究.
KP代谢物概况及其与EGFR和ACE抑制剂的关系为SSc提供了潜在的治疗见解.

关键词:

基努伦酸是什么基努伦酸是什么基努伦酸是什么这种药物是kynurenine.基诺氨酸通路的使用硬化皮质硬化皮质 (scleroderma) 是一种疾病.托芬三聚氨酸是什么

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