孕期糖尿病和腹腔胃口调节阿迪波基因调节胃口
Jolanta Lis-Kuberka1, Marta Berghausen-Mazur2,3, Magdalena Orczyk-Pawiłowicz1
1Division of Chemistry and Immunochemistry, Department of Biochemistry and Immunochemistry, Wroclaw Medical University, M. Skłodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.
International journal of molecular sciences
|April 13, 2024
概括
孕期糖尿病 (GDM) 影响母亲和婴儿的健康. 这项研究发现,与胰岛素治疗或非GDM母亲相比,饮食治疗的GDM母亲的乳牛奶中的格林水平较低.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕期糖尿病 (GDM) 是一种严重的妊娠并发症,对母亲和孩子都有持久的健康影响.
- 胆乳中的食欲调节激素在婴儿营养和代谢编程中起着至关重要的作用.
- 了解GDM严重程度如何影响这些激素对于优化婴儿健康结果至关重要.
研究的目的:
- 调查GDM中母亲高血糖症严重程度对食欲调节分子的结肠度的影响.
- 为了比较饮食治疗的GDM (GDM-G1),胰岛素治疗的GDM (GDM-G2) 和正常血糖妊娠之间的激素水平.
主要方法:
- 从患有GDM的母亲 (N=30) 和正常血糖对照 (N=21) 收集了乳头样本.
- 调节食欲的激素的度,包括 ghrelin,adiponectin,leptin,resistin 和 IGF-I,使用免疫酶测试来测量.
主要成果:
- 与GDM-G2 (0.38 ng/mL) 和非GDM组 (0.36 ng/mL) 相比,GDM-G1组 (0.21 ng/mL) 的结肠 ghrelin水平明显较低.
- 对于与高血糖相关的阿迪波内克丁,莱普,抵抗素或IGF-I水平,没有观察到显著的差异.
- 与对照组 (7.89 ng/mL) 相比,GDM-G1 (13.33 ng/mL) 和GDM-G2 (12.81 ng/mL) 均显示出非显著的趋势,指向更高水平.
结论:
- 在饮食治疗的GDM中观察到的结肠 ghrelin的减少可能会影响婴儿的食欲调节和能量平衡.
- 缺乏其他激素的显著变化可能表明在怀孕期间有效的GDM管理.
- 在GDM中改变的结肠杆激素配置可能会影响后代的代谢恒温和长期健康.
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