骨肌肉热冲击蛋白质含量和重复发作效应
Marius Locke1, Giovanni Bruccoleri1
1Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON M5S 2W6, Canada.
International journal of molecular sciences
|April 13, 2024
概括
重复发作效应 (RBE) 保护骨肌肉免受损伤. 通过延长收缩 (LC) 预先条件增加了热冲击蛋白 (HSP),这可能解释了保护性RBE.
科学领域:
- 骨肌肉生理学 骨肌肉生理学
- 运动诱导的肌肉损伤
- 细胞应激反应的应激反应
背景情况:
- 重复发作效应 (RBE) 描述了肌肉在初始损伤后对损伤的增强抵抗力.
- 热冲击蛋白 (HSP) 被细胞压力上调,可能在肌肉适应中发挥作用.
研究的目的:
- 研究热冲击蛋白 (HSP) 含量与骨肌中的重复发作效应 (RBE) 之间的关系.
- 为了确定延长收缩 (LC) 的预条件是否会影响HSP水平和随后的肌肉保护.
主要方法:
- 斯普雷格-道利大鼠的前肌肉预先得到了0,5,或15个LC.
- 然后在48小时后,肌肉接受了60个LC.
- 测量了HSP含量 (αB-晶体,HSP25,HSP72) 和活动扭矩损失.
主要成果:
- 使用15个LC,但不是5个LC的预条件,显著提高了HSP水平 (αB-晶体,HSP25,HSP72).
- 预先调节的肌肉在60 LC协议期间显著减少了活力扭矩的损失.
- 形态分析表明,在预先条件的肌肉中,肌肉纤维损伤较少.
结论:
- 在预先调节后,骨肌肉中HSP含量升高可能会导致保护性反复发作效应.
- 通过延长收缩来预先调节可以增强肌肉对后续损伤的抵抗力,这种抵抗力可能由高压肌肉介导.
相关概念视频
Muscle Stimulation Frequency
2.2K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.2K
Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
Muscle Recovery and Fatigue
2.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.1K
Relaxation of Skeletal Muscles
3.2K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
3.2K
Motor Unit Stimulation
1.5K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
1.5K


