与衰老相关的神经退行和认知衰退
Irina Alafuzoff1,2, Sylwia Libard1,2
1Department of Pathology, Uppsala University Hospital, 751 85 Uppsala, Sweden.
International journal of molecular sciences
|April 13, 2024
概括
神经病理学评估显示,高酸化 (HPτ) 和粉样β (Aβ) 在老年人中非常普遍. 混合神经病理是痴呆的常见原因,强调了与年龄相关的认知衰退的复杂性.
科学领域:
- 神经病理学神经病理学
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 神经病理变化在老年大脑中很常见,但它们的流行率和痴呆症的同时发生需要进一步调查.
- 了解与年龄相关的蛋白质病变的谱系对于诊断和治疗认知衰退至关重要.
研究的目的:
- 在一大批已故个体中评估高酸化 (HPτ),粉样β (Aβ),TDP-43和α-synuclein病理的流行率.
- 为了确定阿尔茨海默病神经病理变化 (ADNC),初级与年龄相关的病 (PART) 和其他神经退行性疾病的频率.
- 研究这些神经病理与老年人群中痴呆症之间的关联.
主要方法:
- 在乌普萨拉大学医院15年来对1630名已故个体 (≥41岁) 的神经病理评估.
- 过酸化的 (HPτ),粉样β (Aβ),TDP-43和α-synuclein (αS) 蛋白质聚合物的量化.
- 神经病理变化的分类包括ADNC,PART,LATE,LBD,MSA和ARTAG.
主要成果:
- 在98%的受试者 (≥41岁) 中发现了HPτ,在64%的受试者中发现了Aβ. 在56%的ADNC和26%的PART中出现了ADNC.
- 在35%的患者中观察到TDP-43 (LATE),在21%的患者中观察到αS (LBD/MSA). 混合的神经病理很常见,特别是在痴呆病例中 (84%).
- 在293名痴呆患者中,81%的ADNC高/中等. 在53%的痴呆症患者中发现了与年龄相关的星骨病变 (ARTAG).
结论:
- 与年龄相关的蛋白质病变,如HPτ和Aβ在老年人中非常普遍.
- 混合的神经病理状况很常见,经常导致痴呆症,突出显示需要全面的诊断方法.
- 了解各种神经退行性病理的同时发生对于推进研究和老年人群认知障碍的临床管理至关重要.
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