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较低的老年营养风险指数和预后营养指数预测肝细胞癌患者的术后预后

Mariko Tsukagoshi¹, Kenichiro Araki¹, Takamichi Igarashi¹

¹Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, Japan.

|April 13, 2024

概括

营养指数如老年营养风险指数 (GNRI) 和预后营养指数 (PNI) 预测肝癌 (HCC) 患者的结果. 低GNRI或PNI得分与手术后更差的生存率和特定的复发模式相关.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
营养科学营养科学

背景情况:

营养状况越来越被认为是影响癌症患者结果的关键因素.
特定的营养指数,如老年营养风险指数 (GNRI) 和预后营养指数 (PNI),已经显示出在各种恶性瘤中作为预后标志物的潜力.
肝细胞癌 (HCC) 的预后很复杂,确定可靠的术后预测标志物至关重要.

研究的目的:

调查老年营养风险指数 (GNRI) 和预后营养指数 (PNI) 对肝细胞癌 (HCC) 患者术后预后的预测价值.
探索GNRI和PNI之间的关联以及HCC肝切除后的特定复发模式.

主要方法:

对203名患者进行回顾性分析,这些患者接受了针对HCC的初始肝切除术.
根据GNRI (98) 和PNI (45) 的预定义切线,患者被分为不同组.
进行了统计分析,以评估营养指数,临床因素和患者结果之间的关联.

主要成果:

无论是GNRI还是PNI,都显示出与身体组成,肝功能,瘤特征和术后因素的显著关联.
较低的GNRI和PNI得分与更糟糕的整体存活率 (OS) 和无复发存活率显著相关.
患有早期复发或肝外复发的患者的GNRI和PNI得分明显较低.

结论:

老年营养风险指数 (GNRI) 和预后营养指数 (PNI) 可以作为预测HCC患者肝切除后预后和复发模式的宝贵工具.
这些营养指数提供了一种潜在的非侵入性方法来分层风险,并指导肝癌患者的临床管理.

关键词:

老年人的营养风险指数.肝细胞癌是肝细胞癌.肝脏切除切除肝脏切除预后预后预后预后营养指数的预后.复发性复发性复发性

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