支气管肺发育不良症,胰岛素类生长因子I和营养之间的关联
Dana F J Yumani1, Floor H Walschot1, Harrie N Lafeber1
1Division of Neonatology, Department of Pediatrics, Location VU University Medical Center, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Nutrients
|April 13, 2024
概括
胰岛素样生长因子I (IGF-I) 的缓慢增加和更低的妊娠年龄与更高的支气管肺功能失调 (BPD) 风险有关. 捐赠人母乳也可能增加BPD的几率.
科学领域:
- 新生儿医学 新生儿医学
- 儿科肺病学 儿科肺病学
- 内分泌学 在内分泌学.
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的一个重大并发症.
- 胰岛素样生长因子I (IGF-I) 涉及到BPD的发病.
- 营养因素影响IGF-I水平,并可能影响BPD的发展.
研究的目的:
- 调查营养,IGF-I轴和早产婴儿BPD发生之间的关系.
- 为了确定IGF-I和IGFBP-3水平与BPD发展是否相关.
- 评估养习惯,包括捐赠人乳,对BPD风险的影响.
主要方法:
- 86名早产婴儿 (平均妊娠年龄为29.0周) 的观察研究.
- 血清IGF-I和IGFBP-3在出生时和出生后2,4和6周测量.
- 在月经后36周诊断BPD;进行多变量分析.
主要成果:
- 降低IGF-I水平与BPD的几率增加有关 (或0.68每μg/L/周增加).
- 较低的妊娠年龄 (OR 0.44) 和主要的供体母乳养 (OR 7.6) 与BPD发生有关.
- 在多变量分析中,IGFBP-3水平与BPD没有显著的关联.
结论:
- 较慢的IGF-I水平进展和较低的妊娠年龄是BPD的危险因素.
- 供体母乳养可能与BSD风险增加有关,需要进一步调查.
- 了解IGF-I轴和营养影响对于BPD预防策略至关重要.
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