在老年人中,多种微量元素,执行功能和没有痴呆症的认知障碍之间的关联
Seung-Woo Ryoo1, Baek-Yong Choi1, Seok-Yoon Son1
1Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
Nutrients
|April 13, 2024
概括
基本微量元素 (ETE) 可能会保护老年人免受认知障碍. 这项研究发现,多个ETE与没有痴呆症 (CIND) 的认知障碍风险较低有关.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 老年人认知障碍是一个日益严重的公共卫生问题.
- 之前的研究将单个基本微量元素 (ETE) 与认知功能联系起来,但综合效应仍然不清楚.
研究的目的:
- 在韩国老年人中调查多个ETE和没有痴呆症的认知障碍 (CIND) 之间的关联.
- 检查ETE与执行职能之间的关系.
主要方法:
- 贝叶斯核心机器回归 (BKMR) 模型应用于336名老年人.
- 测量血液中 (Mn),铜 (Cu), (Zn), (Se) 和 (Mo) 的含量.
- 使用执行功能测试评估认知功能,包括数字符号编码 (DSC) 和韩国色词Stroop测试 (K-CWST).
主要成果:
- 在多个ETE和CIND的几率之间观察到负相关性.
- (Mn) 与CIND显示出U形关系,被确定为最占主导地位的元素.
- 铜 (Cu) 和 (Se) 与特定执行功能测试 (K-CWST和DSC,分别) 的表现有关.
结论:
- 暴露于ETE组合可能会对老年人认知障碍产生保护作用.
- 像Mn,Cu和Se这样的特定ETE在老年人群中在维持认知健康和执行功能方面发挥着独特的作用.
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