在间歇性禁食后,与持续的食物限制相比,饮食诱导的肥胖大鼠的性取决于性代谢效应
Laia Bosch de Basea1, Marina Boguñà1, Alicia Sánchez1
1Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
Nutrients
|April 13, 2024
概括
与雄性相比,雌性大鼠对连续或间歇的卡路里限制有更大的敏感性,导致更显著的体重减轻和更好的胰岛素敏感性. 这突显了对饮食干预的代谢反应的性别差异.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 间歇性禁食 (IF) 是一种流行的减肥策略,但其代谢效应和性别特异性需要进一步研究.
- 肥胖是一个日益严重的健康问题,了解有效的饮食干预措施至关重要.
- 以前的研究还没有完全阐明不同卡路里限制方法的与性别相关的代谢影响.
研究的目的:
- 为了比较持续热量限制 (CCR) 与间歇热量限制 (ICR) 对雄性和雌性大鼠代谢参数的影响.
- 在已建立的肥胖模型中,研究CCR和ICR对反应的性别相关差异.
- 为了评估体重,能量摄入和肝脏和脂肪组织中的基因表达的变化.
主要方法:
- 雄性和雌性大鼠通过食堂饮食诱导肥胖.
- 每周两天不连续减少75%的能量定义为ICR,而CCR则涉及30%的整体能量减少.
- 评估了体重,能量摄入量,胰岛素敏感性 (HOMA-IR) 和肝脏基因表达 (IRS2,Sirt1).
主要成果:
- 无论是CCR还是ICR,都减少了男性的体重和脂肪量.
- 与男性相比,女性表现出更明显的白色脂肪组织 (WAT) 损失和胰岛素敏感度的更大改善.
- 在女性中观察到肝脏IRS2和Sirt1的升级,但在男性中没有观察到卡路里限制后的男性.
结论:
- 与男性相比,女性对连续和间歇性热量限制都表现出更强的敏感性.
- 卡路里限制策略可以改善代谢健康,对女性来说可能有更大的好处.
- 基于性别的差异是优化减肥和代谢健康的饮食干预措施的关键考虑因素.
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