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减肥手术对肠道微生物群组成的影响及其对大脑和外围点的影响
Sevag Hamamah1, Andras Hajnal2, Mihai Covasa1,3
1Department of Basic Medical Sciences, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA 9176, USA.
Nutrients
|April 13, 2024
概括
减肥手术重塑肠道微生物群和神经激素信号,导致显著的体重减轻和行为变化. 了解这些机制可能会解开新的非手术肥胖治疗方法.
科学领域:
- 代谢手术 代谢手术
- 肠道微生物组研究研究
- 神经内分泌学神经内分泌学
背景情况:
- 肥胖是一个主要的全球健康问题,腹部手术是严重病例的高效治疗方法.
- 减肥手术的影响超越了身体限制,涉及与肠道微生物群和神经激素通路的复杂相互作用.
研究的目的:
- 审查减肥手术对减肥和行为修改的多方面的影响.
- 阐明肠道微生物组和神经激素信号在中介手术结果中的作用.
主要方法:
- 审查关于减肥手术程序的现有文献 (例如,Roux-en-Y胃绕道,袖子胃切除术).
- 对调查肠道微生物群组成和功能术后变化的研究进行分析.
- 检查手术对肠道荷尔蒙和大脑奖励通路的影响.
主要成果:
- 腹腔外科手术显著改变了肠道微生物群,影响了Firmicutes/Bacteroidetes的比率,并增加了像Akkermansia这样的有益细菌.
- 微生物群的转变会影响多巴胺信号和肠道激素 (格林,瘦素,GLP-1,PYY,CCK),减少享乐饮食和增强腹感.
- 代谢副产品,如SCFA和胆酸,对代谢,炎症和食物奖励通路产生影响.
结论:
- 腹腔外科手术通过肠道微生物群和神经激素调节,极大地影响体重调节.
- 了解这些途径为开发针对肠道微生物群和相关信号的新型非手术肥胖干预提供了潜力.
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