哺乳期母亲的减压干预改变了母体肠道,母乳和婴儿肠道微生物组:来自随机对照试验的数据
Jinyue Yu1, Yan Zhang2, Jonathan C K Wells1
1Childhood Nutrition Research Group, Population, Policy & Practice Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
放松干预措施可能会改变母亲和婴儿肠道微生物组. 这项研究探讨了这些变化,包括母乳微生物组的变化,有助于减少母亲的压力和改善婴儿体重增加.
科学领域:
- 微生物组研究的研究.
- 母婴健康 孕产妇和婴儿健康
- 肠-大脑轴 肠-大脑轴
背景情况:
- 研究了母体肠道,母乳和婴儿肠道微生物组在放松干预中的作用.
- 这项干预旨在减少母亲的压力,并促进婴儿的体重增加.
研究的目的:
- 分析母婴微生物组如何调解放松干预的效果.
- 评估肠道微生物组组成和多样性的变化.
主要方法:
- 一个随机对照试验 (RCT) 的二次分析,主要是对母婴.
- 在基线和8周时对便和母乳样本进行16S rRNA基因扩增序列测序.
- 放松干预和对照组之间的微生物组组成和多样性的比较.
主要成果:
- 群体之间的母体肠道微生物组结构的显著差异,随着时间的推移而增加.
- 干预组母乳中较低的α多样性和较高的Bifidobacterium.
- 干预组的婴儿肠道微生物组中的α多样性更高.
结论:
- 这些发现支持了微生物组调解放松干预效应的假设.
- 可能涉及肠-大脑轴和肠-乳腺通路.
- 需要进一步确认以验证这些微生物组介导的效应.
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